| Pair Name | Forskolin, Paclitaxel | ||
| Phytochemical Name | Forskolin (PubChem CID: 47936 ) | ||
| Anticancer drug Name | Paclitaxel (PubChem CID: 36314 ) | ||
| Structure of Phytochemical |
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| Structure of Anticancer Drug |
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| Pair Name | Forskolin, Paclitaxel | |||
| Disease Info | [ICD-11: 2C25.Z] | Lung cancer | Investigative | |
| Biological Phenomena | Induction-->Apoptosis | |||
| Gene Regulation | Up-regulation | Expression | PSMD9 | hsa5715 |
| Down-regulation | Expression | CCNA1 | hsa8900 | |
| Up-regulation | Expression | CDH1 | hsa999 | |
| Down-regulation | Expression | VIM | hsa7431 | |
| Up-regulation | Cleavage | PARP1 | hsa142 | |
| Up-regulation | Cleavage | CASP3 | hsa836 | |
| In Vitro Model | NCI-H1299 | Lung large cell carcinoma | Homo sapiens (Human) | CVCL_0060 |
| A-549 | Lung adenocarcinoma | Homo sapiens (Human) | CVCL_0023 | |
| Result | Our findings encourage the design of future studies aimed at further exploring the Forskolin employment in NSCLC treatment. | |||
| No. | Title | Href |
|---|---|---|
| 1 | Forskolin affects proliferation, migration and Paclitaxel-mediated cytotoxicity in non-small-cell lung cancer cell lines via adenylyl cyclase/cAMP axis. Eur J Cell Biol. 2023 Jun;102(2):151292. doi: 10.1016/j.ejcb.2023.151292. | Click |
